Endocrine Abstracts

Background: The water deprivation test as the accepted gold standard in the differential diagnosis of polyuria polydipsia syndrome can be associated with a decrease in extracellular fluid volume in patients with diabetes insipidus (DI). We herein evaluated mid-regional pro-atrial natriuretic peptide (MR-proANP) as marker of extracellular body volume in patients with diabetes insipidus compared to primary polydipsia (PP), at baseline and after water deprivation.<p class="ab...

Introduction: Despite adequate treatment with LT4 monotherapy, many patients with primary hypothyroidism still report complaints, as this treatment can not exactly imitate the endogenous homeostasis. We examined whether the different domains of HR-QOL were affected by the existence of a thyroid disorder and use of LT4 substitution, and whether a lower ratio of free triiodothyronine (fT3)–free thyroxine (fT4)</sup...

Background: Hyponatremia is common in hospitalized patients and its differential diagnosis and management challenging. An important mechanism is suppressed or adequately or inadequately secreted plasma arginine vasopressin (AVP). Therefore, plasma vasopressin levels may help in the differential diagnosis and in therapy management. Copeptin is secreted in an equimolar ratio to AVP and is more reliable to measure.Methods: In this prospective observational ...

Background: Hyponatremia is the most common electrolyte disturbance in hospitalized patients and associated with a substantial morbidity and mortality. Symptoms of severe hyponatremia vary among patients between nonspecific symptoms such as nausea or malaise or acute life threatening brain oedema. Prospective studies to assess symptoms and mortality in patients with severe hyponatremia are lacking.Methods: In this prospective multicentre observational st...

Background: BAFF is a Serum B cell stimulating factor shown elevated in Graves’ disease, compared to controls (Vannucchi 2012). BAFF and its receptor are expressed on lymphocytes infiltrating the thyroid in Graves’ disease as well as on thyrocytes themselves (Campi 2015).Aims: A single-blind randomized controlled trial (EudraCT 2015-002127-26) has been conducted to test the efficacy of the anti-BAFF monoclonal antibody belimumab (BMB) in acti...

Calcification is physiologically present in bone but also pathophysiologically in the vasculature, favouring cardiovascular diseases. Our aim was to investigate changes in the expression of calcification regulators (CR) during vascular calcification in bone and vasculature. Gene expression levels of OPG, RANKL, OPN, MGP, BSP-II and RUNX2 were determined in bone, aorta and arteria ilica externa tissue samples of 22 transplant donors. Gene expression levels during atheroscleroti...

Introduction: Transsexualism associates biological normality with the conviction of belonging to the opposite sex and the gender reassignment request. The therapy includes psychological, hormonal and surgical treatment. Only limited clinical studies addressing cross-sex hormonal therapy and side effects exist.Methods: Here, we report the results of a drafted questionnaire evaluating etiological aspects and treatment outcome. The questionnaire was distrib...

Graves’ Disease (GD) affects about 2% of the population in the UK, with female predominance. A proportion of GD patients (5–50%) develop orbitopathy (GO), which is characterized by tissue remodeling in the orbit leading to protrusion of the eye (proptosis). Blood biomarkers associated with GD or GO could be useful diagnostic or prognostic tools for researchers and clinicians. Within the framework of INDIGO IAPP-612116 (Investigation of Novel biomarkers and Definition...

Introduction: The endocrinologist is confronted with an increasingly large population of postbariatric patients who present with endocrine problems. One of these is early dumping, a complication that may be the result of increased entero-endocrine activity. To address the prevalence of early dumping and to gain further insight into its pathophysiology, we performed a Mixed Meal Tolerance Test (MMTT) in a random sample of patients after Roux-en-Y gastric bypass (RYGB).<p cl...

BackgroundSerum B cell stimulating factor (BAFF) has been shown to be elevated in Graves’ disease (Vannucchi 2012). In addition, BAFF and its receptor have been shown to be expressed on lymphocytes infiltrating the thyroid in Graves’ disease and also on thyrocytes (Campi 2015).AimsWe tested in a single-blind randomized controlled trial (EudraCT 2015–002127–26) whether the administration ...